Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders.

摘要: Abstract Background Neuroimaging changes in bipolar disorder (BD) may be secondary to the presence of certain clinical factors. Type 2 diabetes mellitus (T2DM) damages brain and frequently co-occurs with BD. Studying patients both T2DM BD could help identify preventable risk factors for neuroimaging Methods We used 1.5T magnetic resonance spectroscopy measure prefrontal N -acetylaspartate (NAA), which is mainly localized neurons, total creatine (tCr), an energy metabolite, 19 insulin resistance/glucose intolerance (BD + IR/GI), 14 subjects T2DM), 15 euglycemic participants, 11 euglycemic, nonpsychiatric control. Results The levels NAA tCr were lowest among T2DM, intermediate IR/GI, highest control ( F 3,55 = 4.57, p .006; 2.92, .04, respectively). Even IR/GI had lower than participants t 43 2.13, .04). Total Cr was associated (β .52, 56 5.57, .000001). Both correlated Global Assessment Functioning scores r 46 .28, .05; .48, .0004, Conclusions but also prediabetes, neurochemical alterations These poor psychosocial functioning indicate impaired metabolism. findings emphasize importance improving care suggest potential options treatment alterations.