Dysmetria of thought: clinical consequences of cerebellar dysfunction on cognition and affect.

摘要: Cognitive and emotional changes might be prominent or even principal manifestations of cerebellar lesions. This realization supports evidence suggesting that the cerebellum is an important part a set distributed neural circuits subserve higher-order processing. Early anecdotal clinical accounts described aberrant mental intellectual functions in setting atrophy. Later systematic analyses showed able to influence autonomic, vasomotor, behaviors, further studies revealed neuropsychological deficits patients with degenerative diseases. Current descriptions behavioral adults children acquired lesions bring debate about role function within realm clinically relevant cognitive neuroscience. The activation focal regions by tasks on functional neuroimaging studies, morphologic abnormalities psychiatric diseases such as autism schizophrenia support this view. Anatomical substrates have been elucidated could cognition emotion. Our concept `dysmetria thought' draws analogy motor system describe explain impairments behavior result when subserving operations are deprived modulation.