Enzymatic cleavage and formation of cyanohydrins: a reaction of biological and synthetic relevance
作者： Herfried Griengl , Andrea Hickel , Dean V. Johnson , Michael Schmidt , Christoph Kratky
DOI: 10.1039/A700907K
关键词:
摘要: Hydroxynitrile lyases (Hnls) catalyse enantioselectively both the cleavage and formation of cyanohydrins. Besides well known (R)-selective enzyme from almonds, (S)-Hnls have recently become available in larger quantities by cloning over-expression. The first three-dimensional structure a Hnl has been established for Hevea brasiliensis. These results are basis still broader application Hnls biocatalytic asymmetric syntheses on preparative scale.
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