RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles

作者: Jorg Heinz Vollmer , Marion Jurk

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摘要: Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such compositions containing are provided according to invention. The incorporating potent selective inducers TLR7 TLR7-associated cytokine IFN-α.

参考文章(12)
Grayson B. Lipford, Alexandra Forsbach, Immunostimulatory viral rna oligonucleotides ,(2005)
Joerg Vollmer, Arthur M. Krieg, Eugen Uhlmann, Ulrike Samulowitz, Semi-soft c-class immunostimulatory oligonucleotides ,(2005)
Jorg Vollmer, Arthur Krieg, Marion Jurk, Eugen Uhlmann, Sequence requirements for inhibitory oligonucleotides ,(2004)
Jorg Vollmer, Arthur M. Krieg, Eugen Uhlmann, Marion Jurk, 5′ CpG nucleic acids and methods of use ,(2003)
Florian Heil, Hiroaki Hemmi, Hubertus Hochrein, Franziska Ampenberger, Carsten Kirschning, Shizuo Akira, Grayson Lipford, Hermann Wagner, Stefan Bauer, Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 Science. ,vol. 303, pp. 1526- 1529 ,(2004) , 10.1126/SCIENCE.1093620
Sabine Hoffjan, Jörg T. Epplen, Toll-like receptors and airway disease Drug Discovery Today: Therapeutic Strategies. ,vol. 3, pp. 317- 324 ,(2006) , 10.1016/J.DDSTR.2006.09.008
Grayson B. Lipford, Stefan Bauer, Hermann Wagner, Immunostimulatory g,u-containing oligoribonucleotides ,(2003)
Arthur M. Krieg, Eugen Uhlmann, Jorg Vollmer, Combination motif immune stimulatory oligonucleotides with improved activity ,(2002)
Ingmar Dr. Hoerr, Florian Von Der MüLBE, Steve Dr. Pascolo, Immunostimulation by chemically modified RNA ,(2003)