摘要: Prostate cancer is one of the common cancers where there good evidence for a larger genetic component to its etiology, but models are complex. It highly likely that PCa predisposition genes will be polygenic and may interacting within families. Some DNA repair (e.g., BRCA2) these account only small proportion young cases. However, discovery high-risk BRCA2 mutations has led first clinical targeted screening trial based on genotype in this disease (the IMPACT study, discussed above), serve as basis further chemoprevention trials identified. The lessons learned uptake male population, psychological issues men at higher risk PCa, utility PSA identification new better biomarkers parameters so
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