作者: Ellen L. Goode , Janet L. Stanford , Lisa Chakrabarti , Mark Gibbs , Suzanne Kolb
DOI: 10.1002/(SICI)1098-2272(200003)18:3<251::AID-GEPI5>3.0.CO;2-X
关键词: Genetic marker 、 Prostate cancer 、 Disease 、 Locus (genetics) 、 Genetics 、 Gene mapping 、 Genetic linkage 、 Demography 、 Prostate 、 Biology 、 Locus heterogeneity
摘要: Confirmation of linkage and estimation the proportion families who are linked in large independent datasets is essential to understanding significance cancer susceptibility genes. We report here on an analysis 150 high-risk prostate (2,176 individuals) for potential HPC1 locus at 1q24-25. This dataset includes 640 affected men with average age diagnosis 66.8 years (range, 39–94), representing largest collection analyzed this region date. Linkage multiple 1q24-25 markers was strongly rejected sample as a whole (lod scores theta = 0 ranged from –30.83 –18.42). Assuming heterogeneity, estimated (alpha) entire 2.6%, using multipoint analysis. Because heterogeneity may lead false rejection linkage, data were stratified based homogeneous subsets. When restricted 21 Caucasian five or more family members mean < 65 years, lod remained less than –4.0. These results indicate that overall portion hereditary whose disease due inherited variation be originally estimated. Genet. Epidemiol. 18:251–275, 2000. © 2000 Wiley-Liss, Inc.