Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia

摘要: The molecular basis accounting for the peculiar clinical and biological features of hairy cell leukaemia (HCL) is currently unknown. Deregulation cycle genes plays a significant role in oncogenesis there considerable evidence suggesting that Cdk inhibitors (Ckis) function as tumour suppressors. We others have recently demonstrated low expression Cki p27 very aggressive neoplasms high-grade lymphomas. To investigate whether HCL cases express normal protein, other low-grade lymphomas with proliferation index, 58 were characterized using sensitive biotin-streptavidin-immunoperoxidase technique specific antibodies against p27. All showed either no or weak reactivity, contrast to types B-cell lymphoma [22 chronic lymphocytic (CLL), 12 gastric marginal (MALT), 16 follicular two splenic zone lymphomas]. possible mechanism(s) observed cells, multiple approaches used. According these studies, levels are not result (1) increased ubiquitin-mediated degradation, (2) decreased transcription (3) somatic mutations and/or allelic loss. These findings suggest protein may be achieved through post-transcriptional regulation. Finally, our data demonstrate does correlate progression cells associated their unique stage differentiation activation yet unknown pathways.