MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer.
作者： M Garofalo , C Quintavalle , G Di Leva , C Zanca , G Romano
DOI: 10.1038/ONC.2008.6
关键词:
摘要: To define novel pathways that regulate susceptibility to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in non-small cell lung cancer (NSCLC), we have performed genome-wide expression profiling of microRNAs (miRs). We show TRAIL-resistant NSCLC cells, levels different miRs are increased, and particular, miR-221 -222. demonstrate these impair TRAIL-dependent apoptosis by inhibiting the key functional proteins. Indeed, transfection with anti-miR-221 -222 rendered CALU-1-resistant cells sensitive TRAIL. Conversely, H460-sensitive treated -221 pre-miRs become resistant target 3'-UTR Kit p27(kip1) mRNAs, but interfere TRAIL signaling mainly through p27(kip1). In conclusion, high needed maintain phenotype, thus making as promising therapeutic targets or diagnostic tool for resistance NSCLC.
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