FceR11/CD23 Receptor Distribution in Patch Test Reactions to Aeroallergens in Atopic Dermatitis

摘要: There is increasing evidence that exposure to organic allergens may induce or exacerbate lesional skin in patients with atopic dermatitis. In this study, dermatitis were patch tested 11 common and control chambers containing 0.4% phenol 50% glycerin 0.9% saline. biopsies from positive test reactions, skin, eczematous non-lesional individuals, normal non-atopic volunteers, the presence distribution of macro- phages (RFD7+), dendritic cells (RFD1+), Langerhans cells, expression low-affinity receptor for IgE (CD23) investigated. reactions samples, inflammatory infiltrates diffusely distributed macrophages T lymphocytes (RFTmix+), (CD1+) seen, latter being present both epidermis dermis. The numbers reduced increased dermis compared their controls. Double staining revealed a change CD23 antigen. many only few within dermal expressed reaction however, proportion CD23+ had phages. Furthermore, these samples an CD1+ cell (RFD1+) marker. These results show following antigen challenge there are marked similarities between phenotype cellular infiltrate biopsies, also demonstrate changing on antigen-presenting cells.