Removal of albumin-bound toxins from albumin-containing solutions: Tryptophan fixed-bed adsorption on activated carbon

作者: M.C. Annesini , V. Piemonte , L. Turchetti

DOI: 10.1016/J.CHERD.2010.01.022

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摘要: Abstract Fixed-bed adsorption on activated carbon is a common blood detoxification technique implemented in liver support devices to remove different types of toxins, among which tryptophan. In this paper, fixed-bed kinetics tryptophan were investigated. Experimental breakthrough curves obtained at feed flow rates, both albumin-free and albumin-containing solutions. A mathematical model based linear driving force mass transfer was used correlate data with solutions; subsequently, the results successfully predict solutions, accounting only for effect albumin over equilibrium.

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