Liver failure: basis of benefit of therapy with the molecular adsorbents recirculating system
作者： Sambit Sen , Rajiv Jalan , Roger Williams
DOI: 10.1016/S1357-2725(03)00045-1
关键词:
摘要: Accumulation of albumin-bound toxins is known to occur in liver failure, and variable extents responsible for the associated end-organ dysfunctions (kidney, circulation, brain). The toxin-binding scavenging functions albumin are exploited dialysis removal these toxins. extracorporeal support device as molecular adsorbents recirculating system (MARS) based on across an albumin-impregnated membrane, using 20% dialysate. Charcoal anion exchange resin columns circuit help cleanse regenerate Clinical studies over last few years have demonstrated proven reduction hyperbilirubinaemia, along with improvement encephalopathy, systemic haemodynamics renal function failure patients, well apparent survival. results larger controlled clinical trials, investigating pathophysiological basis its effect, awaited.
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