Effective bilirubin reduction by single-pass albumin dialysis in liver failure.

摘要: Albumin dialysis is widely accepted as a liver-support technique for patients with liver failure. The Molecular Adsorbent Recirculating System, the albumin technique, has limited use in developing countries because of its technical difficulties and high cost. Therefore, we assessed efficacy more practical modality, single-pass (SPAD), terms bilirubin reduction, marker albumin-bound toxins removal, well patient outcomes. Twelve acute or acute-on-chronic failure who had hyperbilirubinemia (total > 20 mg/dL) were treated SPAD by using 2% human serum dialysate 6 h. treatment significantly improved levels total bilirubin, conjugated urea, creatinine (P < 0.001 all parameters). reduction ratios these four parameters 22.9 +/- 3.8%, 20.9 5%, 19.0 4.1%, 27.7 3.2%, respectively. No significant difference was observed between ammonia before after treatment. changes mean arterial pressures noted during maneuver, representing cardiovascular tolerability. treatment-related complications found. 15-day in-hospital survival 16.7%. However, subgroup moderate severity showed 100% 15-day-survival rate (2 2 patients). In conclusion, salutarily effective reducing procedure safe simply set up.