Role of Phosphorylation in the Regulation of Acetyl CoA Carboxylase Activity

作者: Roger W. Brownsey , Richard M. Denton

DOI: 10.1007/978-1-4684-4874-0_17

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摘要: Insulin increases the rate of fatty acid synthesis in white fat cells,(1–3) brown cells,(4) liver cells,(5–8) and lactating mammary glane(9,10) within a few minutes. Proportionally, most impressive effects insulin appear to occur cells. In contrast, at least adipose tissue liver, hormones that increase concentration cyclic adenosine monophosphate (cAMP) result inhibition synthesis, esepcially presence insulin.(3,11) To date, this has not been clearly demonstrated for tissue—probably because lack adequate vitro preparations these tissues.

参考文章(86)
M. DANIEL LANE, JOEL MOSS, S. EFTHIMIOS POLARIS, Acetyl coenzyme A carboxylase. Current Topics in Cellular Regulation. ,vol. 8, pp. 139- 195 ,(1974) , 10.1016/B978-0-12-152808-9.50011-0
M N Khan, B I Posner, R J Khan, J J Bergeron, Internalization of insulin into rat liver Golgi elements. Evidence for vesicle heterogeneity and the path of intracellular processing. Journal of Biological Chemistry. ,vol. 257, pp. 5969- 5976 ,(1982) , 10.1016/S0021-9258(19)83873-5
P J Blackshear, R A Nemenoff, J Avruch, Preliminary characterization of a heat-stable protein from rat adipose tissue whose phosphorylation is stimulated by insulin Biochemical Journal. ,vol. 204, pp. 817- 824 ,(1982) , 10.1042/BJ2040817
KI-HAN KIM, Regulation of acetyl-CoA carboxylase. Current Topics in Cellular Regulation. ,vol. 22, pp. 143- 176 ,(1983) , 10.1016/B978-0-12-152822-5.50009-9