作者: Maria Grazia Calevo , Nicola Veronese , Francesco Cavallin , Cavicchioli Paola , Massimo Micaglio
DOI: 10.1038/S41372-018-0281-X
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摘要: To compare surfactant administration via supraglottic airway device (SAD) vs. nasal CPAP alone or INSURE. A systematic search of PubMed, EMBASE, SCOPUS, Cochrane Central Register Controlled Trials and Clinicaltrials.gov was performed. Articles meeting inclusion criteria (RCT, SAD, laryngeal mask, I-gel) were assessed Five RCTs eligible. Surfactant SAD reduced the need for intubation/mechanical ventilation (RR 0.57, 95%CI 0.38–0.85) short-term oxygen requirements (MD −8.00, −11.09 to −4.91) compared nCPAP alone. 0.43, 0.31–0.61), but increased 3.10, 0.51–5.69) INSURE approach. In preterm infants with RDS, reduces ventilation. Overall, available literature includes few, small, poor-quality studies. should be limited clinical trials.