Geroprotectors: A Unified Concept and Screening Approaches.

摘要: Although the geroprotectors discovery is a new biomedicine trend and more than 200 compounds can slow aging increase lifespan of model organism, there are still no on market. The reasons may be partly related to lack unified concept geroprotector, accepted by scientific community. Such as system criteria for geroprotector identification classification form basis an analytical anti-aging drugs, help consolidate efforts various research initiatives in this area compare their results. Here, we review existing characteristics based effect survival group individuals or pharmaceutics classes, according proposed mechanism geroprotective action theories aging. After discussing advantages disadvantages these approaches, offer maintenance homeostatic capacity because considered exponential shrinkage leading onset age-related diseases death. Besides, most promising current screening approaches finding geroprotectors. Establishing physiology understanding nature essential putting knowledge into single system. This could useful formulate standards creating Standardization, turn, would allow easier comparison combination experimental data obtained different groups.