Porphyromonas Gingivalis May Seek the Alzheimer's Disease Brain to Acquire Iron from Its Surplus.

摘要: Iron accumulates in the brain of subjects with Alzheimer's disease (AD). Here it promotes aggregation amyloid-β plaques which is abundant. induces neurotoxicity by damaging free radicals and causing oxidative stress areas neurodegeneration. It can also bind to tau AD enhance toxicity through co-localization neurofibrillary tangles induce accumulation these tangles. Porphyromonas gingivalis a key oral pathogen widespread biofilm-induced "chronic" periodontitis, recently, has been suggested have an important role pathogenesis AD. P. obligate requirement for iron. The current paper suggests that seeks brain, where identified, satisfy this need. If correct, iron chelators binding could beneficial effects treatment Indeed, studies from both animal models humans indicated chelators, e.g., lactoferrin, such effects. Lactoferrin inhibit growth proteinases its ability form biofilm.