Oral misoprostol or vaginal dinoprostone for labor induction: A randomized controlled trial

摘要: Abstract Objective: The objective of the study was to compare effectiveness, safety, and side effects low-dose oral misoprostol with vaginal dinoprostone for cervical ripening labor induction. Study Design: Women Bishop score 6 or less admitted induction at term were eligible this randomized controlled trial. Exclusion criteria multiple pregnancy, breech, fetal distress, previous uterine scar. allocation group (20 μg given every 2 hours increased 40 depending on contractions) (2 mg twice, apart) contained in a sealed, opaque, consecutively numbered envelope. Results: Two hundred women (100 each group) included. proportion delivery within 24 56% 62% (relative risk 0.90, 95% CI 0.72-1.14). cesarean section 18% 19%, respectively. median interval delivery, calculated from survival analysis, longer (1305 minutes) compared (1080 minutes). log-rank test not significant (P = .35). Uterine hyperstimulation occurred 9% 14% .27). only difference neonatal outcomes more frequent presence thick meconium .03). Conclusion: We found no terms effectiveness safety between used labor. This regimen avoids excessive contractility noted studies, where higher doses administered intervals. (Am J Obstet Gynecol 2003;188:162-7.)