Cyclosporine A inhibits mitochondrial pyridine nucleotide hydrolysis and calcium release.
作者： Christoph Richter , Michael Theus , Jörg Schlegel
DOI: 10.1016/0006-2952(90)90315-C
关键词:
摘要: Mitochondria participate in the maintenance of cellular Ca2+ homeostasis. Here we show that immunosuppressive drug cyclosporine A at low concentrations inhibits release but not uptake by mitochondria. Prevention is due to inhibition intramitochondrial enzymatic hydrolysis NAD ADP-ribose and nicotinamide. These findings suggest a mechanism which interferes with homeostasis, may be related cytotoxic properties drug.
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