Is the beneficial effect of calcium channel blockers against cyclosporine A toxicity related to a restoration of ATP synthesis
作者： Marie D. Salducci , Anne M. Chauvet‐Monges , Bertrand M. Dussol , Yvon F. Berland , Aimé D. Crevat
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摘要: ATP synthesis inhibited by Cyclosporine A is restored calcium channel blockers: nifedipine, verapamil, bepridil, diltiazem. was estimated using liver mitochondria measuring the rate of respiration during state 3 and a measure yield synthesis, P/O ratio. The study fluxes through mitochondrial membrane indicates that blockers counteract storage induced A. If restoration observed in vitro also occurred vivo, increase pool might contribute to better functioning Ca2+ extrusion pumps cells, thereby maintaining cytosolic concentration (Cai) normal range. nephrotoxicity appears be due vasoconstrictive effect related an increased Cai This result may account for reduction clinical toxicity blockers. Verapamil most efficient restoring synthesis.
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