The restoration of ATP synthesis may explain the protective effect of calcium antagonists against cyclosporine a nephrotoxicity
作者： M.D. Salducci , A.M. Chauvet-Monges , Y. Berland , B. Dussol , R. Elsen
DOI: 10.1016/0024-3205(92)90571-6
关键词:
摘要: Abstract Cyclosporine A at pharmacological doses decreases the rate and yield of ATP synthesis in rat mitochondria. This action seems to be due mitochondrial calcium storage induced by drug. If such an effect occurs vivo, deficit will affect extrusion pumps, so triggering vasoconstruction which is major side A. Calcium antagonists (Nifedipine Verapamil) least partially correct this on : finding may related with beneficial clinical conferred toxicity antagonists. interaction level efflux.
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sci-hub.se 参考文章(18)
Ildikó Szabó, M Zoratti, The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A. Journal of Biological Chemistry. ,vol. 266, pp. 3376- 3379 ,(1991) , 10.1016/S0021-9258(19)67802-6
R Vargas, P W Ramwell, A Rego, K R Suarez, M L Foegh, Mechanism of cyclosporin potentiation of vasoconstriction of the isolated rat mesenteric arterial bed: role of extracellular calcium. Journal of Pharmacology and Experimental Therapeutics. ,vol. 254, pp. 799- 808 ,(1990)
Orla McGUINNESS, Nasser YAFEI, Andreas COSTI, Martin CROMPTON, The presence of two classes of high‐affinity cyclosporin A binding sites in mitochondria FEBS Journal. ,vol. 194, pp. 671- 679 ,(1990) , 10.1111/J.1432-1033.1990.TB15667.X
Christoph Richter, Michael Theus, Jörg Schlegel, Cyclosporine A inhibits mitochondrial pyridine nucleotide hydrolysis and calcium release. Biochemical Pharmacology. ,vol. 40, pp. 779- 782 ,(1990) , 10.1016/0006-2952(90)90315-C
G. A. Porter, Cyclosporine-associated hypertension. National High Blood Pressure Education Program Archives of Internal Medicine. ,vol. 150, pp. 280- 283 ,(1990) , 10.1001/ARCHINTE.150.2.280
Klaus Jung, Monika Pergande, Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria FEBS Letters. ,vol. 183, pp. 167- 169 ,(1985) , 10.1016/0014-5793(85)80977-7
J P Rapp, Aortic responses to vanadate: independence from (Na,K)-ATPase and comparison of Dahl salt-sensitive and salt-resistant rats. Hypertension. ,vol. 3, ,(1981) , 10.1161/01.HYP.3.3_PT_2.I168
A. J.B. KIRK, I. OMAR, D. N. BATEMAN, J. H. DARK, Cyclosporine-associated hypertension in cardiopulmonary transplantation. The beneficial effect of nifedipine on renal function. Transplantation. ,vol. 48, pp. 428- 429 ,(1989) , 10.1097/00007890-198909000-00015
Brian M. Murray, Mark S. Paller, Thomas F. Ferris, Effect of cyclosporine administration on renal hemodynamics in conscious rats Kidney International. ,vol. 28, pp. 767- 774 ,(1985) , 10.1038/KI.1985.196
JohnJ Curtis, Eva Dubovsky, JohnD Whelchel, RobertG Luke, ArnoldG Diethelm, Patricia Jones, None, CYCLOSPORIN IN THERAPEUTIC DOSES INCREASES RENAL ALLOGRAFT VASCULAR RESISTANCE The Lancet. ,vol. 328, pp. 477- 479 ,(1986) , 10.1016/S0140-6736(86)90355-7