Aggressive angiomyxoma of pelvic soft parts: a clinicopathologic study of nine cases.

摘要: Nine cases of aggressive angiomyxoma (AAM) the pelvic soft parts were studied by light and electron microscopy immunohistochemistry. The tumors confined to vulva, vagina, floor, perineum in seven women. para-anal region involved two men. patients ranged age from 18 63 years. Aggressive presented as a slowly growing, polypoid or cyst-like tumor. Six nine followed up; all recurred within 84 months, one for second time at 144 months. Recurrences attributed incomplete tumor excision. None six died had metastases. angiomyxomas infiltrative borders rubbery, white soft, gelatinous cut surfaces. Histologically, lesions composed stellate spindleshaped neoplastic cells embedded collagenous hyaluronic acid-containing stroma. Nuclear atypia mitoses absent. Typically, an important vascular component, often displaying medial hypertrophy grouping. Ultrastructurally, resembled fibroblasts rather than myofibroblasts. They showed strong immunoreactivity actin but negative S-100 protein, Factor VIII, carcinoembryonic antigen, keratin. morphoimmunocytochemical characteristics AAM favor fibroblastic origin differentiation. should be distinguished more common benign malignant myxoid neoplasms tumor-like conditions parts. Recurrence may avoided wide, local