Serum sTWEAK levels in chronic periodontitis and type 2 diabetes mellitus.

摘要: Abstract Aim The two-way relationship between diabetes mellitus and periodontitis has been extensively studied with various interconnected biomarkers sharing a link. Soluble Tumour Necrosis Factor-like Weak inducer of apoptosis (sTWEAK) is gaining attention as an important mediator in chronic inflammatory diseases. Thus, the aim this study was to detect, estimate compare levels sTWEAK serum health, (CP), CP type 2 (T2DM). Materials methods Forty-five participants 18 65 years were divided into groups 15 each Group 1: healthy, 2: CP, 3: CP + T2DM. Clinical periodontal parameters glycemic status assessed. estimated using commercially available ELISA kit. data statistically analyzed. Results detected all participants. Significant differences observed for sTWEAK; highest lower lowest In diseased groups, clinical correlated positively other, whereas negatively parameters. Conclusion literature reports concentrations systemic T2DM which may be comparable our observations CP + T2DM when compared health its negative correlation suggesting association both levels. However, not necessarily elevated previously reported, hence potential clarification T2DM.