Dihydropyridines As Antihypertensive Agents

摘要: Vascular smooth muscle tone is increased by inward transmembrane flux of Ca2+ through voltage-dependent and receptor-operated channels, as well from intracellular stores. Calcium entry blockers selectively reversibly reduce the influx into cell membrane bound sites within cell. The ability channel to relax vascular and, therefore, decrease peripheral resistance makes them useful antihypertensive drugs. Nifedipine best known example 1,4-dihydropyridine group blockers, which also includes nitrendipine, nisoldipine, nimodipine. effective in lowering blood pressure patients with arterial hypertension has a rapid onset action, nifedipine eminently suitable for emergency treatment hypertension. In chronic therapy, an drug few contraindications side effects.