Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells

摘要: Crosslinking of immunoreceptor tyrosine-based activation motif (ITAM)-containing receptor complexes on a variety cells leads to their through the sequential triggering protein tyrosine kinases. Recently, DAP12 has been identified as an ITAM-bearing signaling molecule that is noncovalently associated with activating isoforms MHC class I receptors natural killer cells. In addition cells, expressed in peripheral blood monocytes, macrophages, and dendritic suggesting association other present these cell types. study, we report molecular cloning myeloid DAP12-associating lectin-1 (MDL-1), membrane exclusively monocytes macrophages. MDL-1 type II transmembrane belonging C lectin superfamily contains charged residue region enables it pair DAP12. MDL-1/DAP12 J774 mouse macrophage resulted calcium mobilization. These findings suggest via may constitute significant pathway