Chronic oral Silybum Marianum aqueous extract attenuates streptozotocin-diabetic neuropathy

摘要: Background : Oxidative stress is implicated as a final common pathway in the development of diabetic neuropathy and pharmacological interventions targeted at inhibiting free radical production have shown beneficial effects. Since Silybum Marianum (SM) plant rich phenolics which their role against oxidative inflammation been prior studies, we tried to determine protective effect of  aqueous extract SM streptozotocin (STZ)-induced rats. Methods: Male wistar rats (n =40) were randomly divided into 4 groups, i.e. Vehicle-treated control (VC), Extract-treated (EC), (VD), diabetic(ED) groups. Animals VC, EC, VD ED groups received sterile saline or plus (200mg/kg) orally for 8 weeks. Diabetes was induced by single intraperitoneal injection STZ (60 mg/kg). Results: We found significant reduction motor nerve conduction velocity, tail flick latency hot immersion test hyperalgesia both phases formalin compared age matched non-diabetic treatment significantly improved velocity nociception The changes lipid peroxidation status anti-oxidant enzyme (Superoxide dismutase) levels observed restored treatment. Conclusion: This study provides experimental evidence on function animal model neuropathy.