Essential Fatty Acid Deficiency Profiles in Idiopathic Immunoglobulin A Nephropathy
作者： Ralph T. Holman , Susan B. Johnson , Douglas Bibus , Dorothy C. Spencer , James V. Donadio
DOI: 10.1016/S0272-6386(12)70274-3
关键词:
摘要: The profiles of fatty acids (FAs) plasma phospholipids (the compartment reflecting the essential FA status tissue lipids), nonesterified FAs precursor pool for autacoid synthesis), urine protein excretion, and glomerular filtration rate were measured before after supplementation with fish oil in 15 patients immunoglobulin A nephropathy. In profiles, there was deficient 18:3 omega 3 (alpha-linolenic acid), parent compound polyunsaturated FA, chain elongation products both 6 replacement by saturated monounsaturated short-chain, odd-chain, branched-chain FAs, producing significant loss FA. These alterations indicate nutritional or functional (omega 3) metabolic 6) deficiencies. Additionally, mean melting point significantly increased, implying an inherent decrease cell membrane fluidity. Enhancement 20: 5 (eicosapentaenoic acid) 22:6 (docosahexaenoic suppression 20:4 (arachidonate) accompanied important decreases proteinuria improved rate. Omega-3 may favorably influence nephropathy through a modulation pathologic actions eicosanoids other diverse on various mediators produced initial immune injury.
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