ERGIC-53 and traffic in the secretory pathway.
作者： H.P. Hauri , H. Andersson , C. Appenzeller , F. Kappeler
关键词:
摘要: The ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 is a mannose-specific membrane lectin operating as cargo receptor for the transport of glycoproteins from ER to ERGIC. Lack functional leads selective defect in secretion cultured cells and hemophilia humans. Beyond its interest receptor, an attractive probe studying numerous aspects protein trafficking secretory pathway, including traffic routes, mechanisms anterograde retrograde traffic, retention proteins ER, function Understanding these fundamental processes cell biology will be crucial elucidation treatment many inherited acquired diseases, such cystic fibrosis, Alzheimer's disease viral infections.
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