Thyroglobulin mRNA expression helps to distinguish anaplastic carcinoma from angiosarcoma of the thyroid.

摘要: The existence of angiosarcoma (AS) the thyroid has been a matter debate for many years, because some authors believe that most if not all ASs are in fact "angiomatoid" anaplastic carcinomas (ACs). Immunohistochemistry alone was successful solving problem, since cytokeratin expression is known occurrence AS. Therefore, we wanted to compare nine cases AS with ten AC, assessing whether thyroglobulin (TG) mRNA still transcribed undifferentiated tumors and could be helpful distinguish AC from were analyzed TG by means radioactive situ hybridization. silver grains counted using an automated device, their amount compared stroma, background, peritumoral thyroid. A weak signal present but (mean counts 35.7 9.6 arbitrary units, respectively: P<0.01). In two residual areas poorly differentiated insular carcinoma had strong (similar thyroid). These findings further confirm unrelated malignant tumors.