Roles of DNA helicases in the mediation and regulation of homologous recombination.

摘要: Homologous recombination (HR) is an evolutionarily conserved process that eliminates DNA double-strand breaks from chromosomes, repairs injured replication forks, and helps orchestrate meiotic chromosome segregation. Recent studies have shown helicases play multifaceted roles in HR mediation regulation. In particular, the S. cerevisiae Sgs1 helicase its human ortholog BLM are involved not only resection of primary lesion to generate single-stranded prompt assembly machinery, but they also function somatic cells suppress formation arm crossovers during HR. On other hand, Mph1 Srs2 helicases, their respective functional equivalents eukaryotes, spurious events favor noncrossovers via distinct mechanisms. Thus, integrity outcomes dependent upon these enzymes. Since mutations some lead cancer predisposition humans mice, on them clear relevance health disease.