Lack of Skeletal Muscle Serotonin Impairs Physical Performance.

摘要: Low levels of the neurotransmitter serotonin have been associated with onset depression. While traditional treatments include antidepressants, physical exercise has emerged as an alternative for patients depressive disorders. Yet there remains fundamental question how is sensed by brain. The existence a muscle-brain endocrine loop proposed: according to this scenario, modulates metabolization tryptophan into kynurenine within skeletal muscle, which in turn affects brain, enhancing resistance But breakdown during may also alter synthesis and help limit In study, we investigated whether peripheral might play role communication permitting adaptation endurance training. We first quantified metabolites blood 4 trained athletes before after long-distance trail race correlated changes metabolism performance. parallel, assess capacity control serotonin-deficient mice, used treadmill incremental test. Peripheral mice exhibited significant drop performance despite Brain were similar wild-type animals, no products muscle-induced found plasma or brains mice. mass spectrometric analyses revealed decrease 5-hydroxyindoleacetic acid (5-HIAA), main metabolite, both soleus plantaris muscles, demonstrating that muscles essential light these findings, but not brain appears be rate-limiting step muscle data suggest mechanism responsible positive effects exercise, are secretory organs autocrine-paracrine roles local effect.