Genetic Susceptibility to Coronary Heart Disease in Type 2 Diabetes
作者： Lu Qi , Layla Parast , Tianxi Cai , Christine Powers , Ernest V. Gervino
DOI: 10.1016/J.JACC.2011.08.054
关键词:
摘要: Objectives The aim of this study was to evaluate whether coronary heart disease (CHD)-susceptibility loci identified by genome-wide association studies the general population also contribute CHD in type 2 diabetes. Background No has examined effects these genetic variants on diabetic patients. Methods We genotyped 15 markers 12 3 patients: prospective Nurses' Health Study (309 cases, and 544 control subjects) Professional Follow-up (345 451 cross-sectional Joslin Heart (422 435 subjects). Results Five single-nucleotide polymorphisms, rs4977574 ( CDKN2A/2B ), rs12526453 PHACTR1 rs646776 CELSR2-PSRC1-SORT1 rs2259816 HNF1A rs11206510 PCSK9 ) showed directionally consistent associations with studies, combined odds ratios (ORs) ranging from 1.17 1.25 (p = 0.03 0.0002). None other polymorphisms reached significance individual or analyses. A risk score (GRS) created combining alleles 5 significantly associated loci. OR CHD/GRS unit 1.19 (95% confidence interval: 1.13 1.26; p Conclusions Our results illustrate consistency differences determinants susceptibility patients populations.
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