Taste disorders are partly genetically determined: Role of the TAS2R38 gene, a pilot study.
作者： Melania Melis , Lisa Grzeschuchna , Giorgia Sollai , Thomas Hummel , Iole Tomassini Barbarossa
DOI: 10.1002/LARY.27828
关键词:
摘要: Objectives/hypothesis Taste sensitivity varies greatly among individuals influencing eating behavior and health, consequently the disorders of this sense can affect quality life. The ability to perceive bitter thiourea compounds, such as phenylthiocarbamide (PTC), has been largely reported a marker general taste sensitivity, food preferences, health. PTC is mediated by TAS2R38 receptor its genetic common variants. We study role in with aim understanding if these be genetically determined. Study design Prospective cohort study. Methods Differences responsiveness between patients healthy controls were assessed. All subjects received standardized tests for smell function genotyped gene. Results PAV/PAV homozygous gave high ratings, whereas PAV/AVI genotypes lower values, which are similar those determined AVI/AVI or rare genotypes. In addition, did not meet Hardy-Weinberg equilibrium at locus, showing very low frequency carrying diplotype. Independently, who heterozygous rated bitterness higher compared Conclusions Our findings, that an only taster haplotype (PAV) sufficient evoke responses disorders, suggest constitution may represent risk factor development disorders. Level evidence 2c Laryngoscope, 129:E307-E312, 2019.
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