MicroRNA-410 functions as a tumor suppressor by targeting angiotensin II type 1 receptor in pancreatic cancer

摘要: MicroRNAs (miRNAs) act as key regulators of gene expression in diverse biological processes and are intimately involved tumorigenesis. However, the underlying molecular mechanisms miR-410 pancreatic cancer remain poorly understood. In this study, we found that overexpression suppressed cell growth vitro vivo well invasion migration. also resulted G1/S cell-cycle arrest. We then showed angiotensin II type 1 receptor (AGTR1) was a direct target miR-410, with suppressing AGTR1 levels. contrast, inhibition increased AGTR1. Silencing inhibited invasion, similar to overexpression. addition, induction vascular endothelial factor activation ERK signaling pathway by were blocked inhibitor losartan. angiogenesis mice through repression CD31 expression. knockdown proliferation, angiogenesis. Finally, downregulated tissues compared adjacent nontumor tissues, whereas upregulated tissues. Pearson correlation analysis inversely expressed. conclusion, our data indicate suppresses growth, migration, via downregulation AGTR1, acting tumor-suppressive miRNA. results suggest is potential diagnostic biomarker therapeutic for patients cancer. © 2015 IUBMB Life, 67(1):42–53,