Determination of acetaminophen concentrations in serum by high-pressure liquid chromatography.

摘要: We describe a method for determination of serum acetaminophen concentrations in by reversed phase high-pressure liquid chromatography. The homolog N-propionyl-p-aminophenol was used as an internal standard. procedure, which requires only single extraction with diethyl ether, can be optimized to linear over the ranges 10 100 or 1 20 mg/liter. Within-run CV 1.2%; between-run 4.4% and 4.9% at two different concentrations. Many commonly drugs were tested found not interfere. procedure is simple rapid enough use on emergency basis cases overdosage, measurement either therapeutic toxic