Influence of processing and curing conditions on beads coated with an aqueous dispersion of cellulose acetate phthalate.
作者： Robert O. Williams III , Jiping Liu
DOI: 10.1016/S0939-6411(00)00065-5
关键词:
摘要: Abstract The influence of fluidized-bed processing conditions, as well curing parameters with and without humidity, on drug release from beads coated cellulose acetate phthalate (CAP) aqueous dispersion was investigated. Theophylline prepared by extrusion–spheronization were diethyl (DEP)-plasticized CAP (Aquacoat ® CPD) using a Strea-1 coater. investigated plasticizer level, outlet temperature, spray rate during coating application fluidizing air velocities half-factorial design. temperature applications identified critical factor among the variables significantly decreased when at 36°C compared to those 48°C ( P
elsevier.com
sci-hub.se 参考文章(19)
Sakae Obara, James W. McGinity, Properties of free films prepared from aqueous polymers by a spraying technique. Pharmaceutical Research. ,vol. 11, pp. 1562- 1567 ,(1994) , 10.1023/A:1018949502392
R. O. Williams, J. Liu, T. A. Wheatley, Influence of plasticization and curing conditions on the mechanical properties of aqueous-based cellulose acetate phthalate films Stp Pharma Sciences. ,vol. 9, pp. 545- 553 ,(1999)
Satoru WATANO, Kiyomi YOSHIKAWA, Kei MIYANAMI, Evaluation of Aqueous Enteric Coated Granules Prepared by Moisture Control Method in Tumbling Fluidized Bed Process Chemical & Pharmaceutical Bulletin. ,vol. 42, pp. 663- 667 ,(1994) , 10.1248/CPB.42.663
Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms CRC Press. ,(2016) , 10.1201/9781315369938
S Obara, Influence of processing variables on the properties of free films prepared from aqueous polymeric dispersions by a spray technique International Journal of Pharmaceutics. ,vol. 126, pp. 1- 10 ,(1995) , 10.1016/0378-5173(95)04057-9
J.T. Heinämäki, A. Iraizoz Colarte, A.J. Nordström, J.K. Yliruusi, Comparative evaluation of ammoniated aqueous and organic-solvent-based cellulose ester enteric coating systems: a study on free films International Journal of Pharmaceutics. ,vol. 109, pp. 9- 16 ,(1994) , 10.1016/0378-5173(94)90116-3
C. A. ENTWISTLE, R. C. ROWE, Plasticization of cellulose ethers used in the film coating of tablets. Journal of Pharmacy and Pharmacology. ,vol. 31, pp. 269- 272 ,(2011) , 10.1111/J.2042-7158.1979.TB13499.X
Dawn Hutchings, Stephen Clarson, Adel Sakr, Studies of the mechanical properties of free films prepared using an ethylcellulose pseudolatex coating system International Journal of Pharmaceutics. ,vol. 104, pp. 203- 213 ,(1994) , 10.1016/0378-5173(94)90161-9
M. E. Aulton, M. H. Abdul-Razzak, J. E. Hogan, The Mechanical Properties of Hydroxypropylmethylcellulose Films Derived from Aqueous Systems Part 1: The Influence of Plasticisers Drug Development and Industrial Pharmacy. ,vol. 7, pp. 649- 668 ,(1981) , 10.3109/03639048109055689
Marc S. Gordon, Anthony Fratis, Ronald Goldblum, Donald Jung, Kenneth E. Schwartz, Zak T. Chowhan, In vivo and in vitro evaluation of four different aqueous polymeric dispersions for producing an enteric coated tablet International Journal of Pharmaceutics. ,vol. 115, pp. 29- 34 ,(1995) , 10.1016/0378-5173(94)00230-3