Controlled magnetosomes: Embedding of magnetic nanoparticles into membranes of monodisperse lipid vesicles

摘要: Magnetic nanoparticle-containing capsules have been proposed for many uses, including triggered drug delivery and imaging. Combining superparamagnetic iron oxide nanoparticles (SPIONs) with existing liposome technology is an enticing near-future prospect, but it requires efficient methods of synthesis formulation compatible pharmaceutical applications. We report a facile way producing large, unilamellar, homogeneously sized magnetoliposomes high content monodisperse, hydrophobic SPIONs integrated in the lipid membrane by use solvent inversion technique. For low concentrations, unilamellar monodisperse vesicles were obtained that became increasingly multilamellar higher fraction. Both, co-self-assembled structure loading significantly influenced purity nanoparticle shell. homogeneous shells nitrodopamine-anchored dispersants could be quantitatively loaded up to 20%w/w, while also containing residual physisorbed oleic acid exhibited cut-off around 10%w/w accompanied drastic changes size distribution. Lipid acyl chain length crucially formation resultant stability assemblies. The nanoparticle-loaded exemplified different biologically important media, yielding ready-to-use magnetoliposome formulations.