Short cationic antimicrobial peptides display superior antifungal activities toward Candidiasis and Onychomycosis in comparison with Terbinafine and Amorolfine
作者： Wenche Stensen , Rob Turner , Marc Brown , Nahid Kondori , John Sigurd Svendsen
DOI: 10.1021/ACS.MOLPHARMACEUT.6B00654
关键词:
摘要: Novel antifungals are in high demand due to the challenges associated with resistant, persistent, and systemic fungal infections. Synthetic mimics of antimicrobial peptides emerging as a promising class compounds for antifungal treatment. In current study, five synthetic cationic tripeptides were evaluated therapeutics against 24 pathogenic strains fungi. Three displayed strong general properties at low micromolar inhibitory concentrations. The most peptide, compound 5, was selected an remedy Candida albicans candidiasis human skin model treatment Trichophyton rubrum induced onychomycosis infected nail model. Compound 5 shown display rapid mode action superior those both commercial comparators Loceryl Lamisil. also active clinical isolate acquired fluconazole resis...
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