Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice.

摘要: Voluntary physical exercise (wheel running, RUN) and environmental enrichment (ENR) both stimulate adult hippocampal neurogenesis but do so by different mechanisms. RUN induces precursor cell proliferation, whereas ENR exerts a survival-promoting effect on newborn cells. In addition, continued prevented the physiologically occurring age-related decline in dentate gyrus did not lead to corresponding increase net neurogenesis. We hypothesized that absence of appropriate cognitive stimuli potential for could be realized an increased proliferating cells due actually more if stimulus follows exercise. thus asked whether sequential combination (RUNENR) would show additive effects are distinct from application either paradigm alone. found 10 days followed 35 were combined stimulation yielded approximately 30% greater new neurons than alone, which also Surprisingly, this result indicates although overall amount is poorly predictive neurogenesis, neurogenic nevertheless provides basis efficiency same stimulus. propose activity can “prime” region case animal exposed additional stimulus, here represented paradigm.