Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
作者： S. W. Scheff , D. A. Price , F. A. Schmitt , S. T. DeKosky , E. J. Mufson
DOI: 10.1212/01.WNL.0000260698.46517.8F
关键词:
摘要: Objective: To evaluate the total number of synapses in stratum radiatum (str rad) human hippocampal CA1 subfield individuals with mild Alzheimer disease (mAD), cognitive impairment (MCI), or no (NCI) and determine if synapse loss is an early event progression disease. Methods: Short postmortem autopsy tissue was obtained, unbiased stereologic sampling scheme coupled transmission electron microscopy used to directly visualize synaptic contacts. Results: Individuals mAD had fewer (55%) than other two diagnostic groups. MCI a mean value that 18% lower NCI group mean. The showed correlation several tests including those involving both immediate delayed recall. Total numbers relationship subject9s Braak stage APOE genotype. volume str rad reduced vs groups were not different from each other. Conclusion: These results strongly support concept structural correlate involved very decline (mAD) supports as transitional between impairment.
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