The source of protein in the aqueous humor of the normal monkey eye.

摘要: In vivo aqueous fluorophotometry, morphology, and computational modeling were combined to examine the source of protein pathway by which enters humor monkeys. A model was developed determine likelihood a diffusional route for delivering plasma proteins from ciliary body capillaries via iris anterior chamber humor, bypassing posterior chamber. Model predictions compared fluorophotometric data obtained monkeys following single intravenous injection fluoresceinated horseradish peroxidase (F-HRP, 250 mg/kg mass). magnitude time course F-HRP concentration agree with measurements. For example, as percentage initial at 90 min 180 post-injection predicted be 0.02% 0.05%, respectively, measured 0.01-0.03% 0.03-0.06%, respectively. addition, in case constant level also are consistent experimental data. The steady-state total 0.2% assayed 0.05-0.2%. As our previous study normal rabbit eye, morphologic tracer localization evidence good agreement between lead conclusion that significant amount normally present monkey originates diffuses anteriorly through into