The effect of endogenous L-phenyllactate on oxalate, glycolate, and glyoxylate excretion by phenylketonuric subjects.

摘要: Approximately 70% of all urinary tract stones contain oxalate. Endogenous oxalate synthesis is an important source which, in theory, should be reduced by inhibiting a key enzyme formation. Glycolic acid oxidase such which can inhibited rats feeding them dl-phenyllactate. Since patients with phenylketonuria (PKU) produce abnormally large amounts l-phenyllactate, it would expected, under this hypothesis, that endogenous these patients; however, their urine was found to elevated levels both and the precursors, glycolate glyoxylate. The level probably formed from aromatic α-ketoacids, are known PKU also precursors result inhibition glycolic oxidase. theory reduce biosynthesis supported two findings: (1) significant (p < 0.05) negative correlation l-phenyllactate (2) positive glycolate. Consequently, concluded inhibits subjects despite increased formation α-ketoacids. Phenyllactate should, therefore, useful reducing idiopathic recurrent kidney stones, ethylene glycol intoxication, primary hyperoxaluria, if required therapeutic dosage does not prove too large.