A Highly Efficient Copper(I)-Catalyzed Cascade Reaction of o-Alkenylphenyl Isothiocyanates with Isocyanides Leading to 5H-Benzo[d]imidazo[5,1-b][1,3]thiazines
作者： Wenyan Hao , Jian Huang , Shanshan Jie , Mingzhong Cai
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摘要: The highly efficient copper(I)-catalyzed cascade reaction of (E)-3-(2-isothiocyanatophenyl)acrylates and (E)-3-(2-isothiocyanatophenyl)acrylonitriles with isocyanides was explored. method provides an expedient route for the synthesis 5H-benzo[d]imidazo[5,1-b][1,3]thiazines in good to excellent yields by using CuCl (10 mol-%) as catalyst K3PO4 (2.0 equiv.) base THF at 70 °C. involves [3+2] cycloaddition subsequent intramolecular C–S bond formation.
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