Chiral salen-aluminum complex as a catalyst for enantioselective alpha-addition of isocyanides to aldehydes: asymmetric synthesis of 2-(1-hydroxyalkyl)-5-aminooxazoles.
作者： Shi-Xin Wang , Mei-Xiang Wang , De-Xian Wang , Jieping Zhu
DOI: 10.1021/OL7014658
关键词: Alpha (ethology) 、 Catalysis 、 Organic chemistry 、 Chemistry 、 Addition reaction 、 Salen-aluminum complex 、 Medicinal chemistry 、 Enantioselective synthesis
摘要: In the presence of a catalytic amount (salen)Al(III)Cl complex (4e), reaction between α-isocyanoacetamides (1) and aldehydes (2) afforded corresponding 5-aminooxazoles (3) in good yields enantioselectivity.
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