Application of molecular genetics to the early diagnosis and screening of lung cancer.

摘要: Abstract Recent studies of the molecular biology lung cancer have identified multiple abnormalities. Despite this vast cataloging genetic lesions, chronology these events and those which occur early remains essentially unknown. This review summarizes abnormalities in cells, including mutation, amplification, overexpression dominant protooncogenes as well deletion mutation recessive oncogenes. In addition, possible candidate genes exist may participate activation cancer, evidence for their role development is discussed. These lesions be helpful developing strategies to screen cancer.