Aspirin, PIK3CA mutation, and colorectal-cancer survival.

Niels Smakman, Inne H.M. Borel Rinkes, Paul van Diest, Alexander L.A. Bloemendaal, Jan M. Vogten, Onno Kranenburg, Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases. Clinical Cancer Research. ,vol. 11, pp. 41- 48 ,(2005)

Pablo Rodriguez-Viciana, Patricia H. Warne, Ritu Dhand, Bart Vanhaesebroeck, Ivan Gout, Michael J. Fry, Michael D. Waterfield, Julian Downward, PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS Nature. ,vol. 370, pp. 527- 532 ,(1994) , 10.1038/370527A0

Giorgia Migliardi, Francesco Sassi, Davide Torti, Francesco Galimi, Eugenia R. Zanella, Michela Buscarino, Dario Ribero, Andrea Muratore, Paolo Massucco, Alberto Pisacane, Mauro Risio, Lorenzo Capussotti, Silvia Marsoni, Federica Di Nicolantonio, Alberto Bardelli, Paolo M. Comoglio, Livio Trusolino, Andrea Bertotti, Inhibition of MEK and PI3K/mTOR Suppresses Tumor Growth but Does Not Cause Tumor Regression in Patient-Derived Xenografts of RAS-Mutant Colorectal Carcinomas Clinical Cancer Research. ,vol. 18, pp. 2515- 2525 ,(2012) , 10.1158/1078-0432.CCR-11-2683

Mai Yamauchi, Teppei Morikawa, Aya Kuchiba, Yu Imamura, Zhi Rong Qian, Reiko Nishihara, Xiaoyun Liao, Levi Waldron, Yujin Hoshida, Curtis Huttenhower, Andrew T Chan, Edward Giovannucci, Charles Fuchs, Shuji Ogino, Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum Gut. ,vol. 61, pp. 847- 854 ,(2012) , 10.1136/GUTJNL-2011-300865

Andrea Sartore-Bianchi, Miriam Martini, Francesca Molinari, Silvio Veronese, Michele Nichelatti, Salvatore Artale, Federica Di Nicolantonio, Piercarlo Saletti, Sara De Dosso, Luca Mazzucchelli, Milo Frattini, Salvatore Siena, Alberto Bardelli, PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Research. ,vol. 69, pp. 1851- 1857 ,(2009) , 10.1158/0008-5472.CAN-08-2466

Shuji Ogino, Katsuhiko Nosho, Gregory J. Kirkner, Kaori Shima, Natsumi Irahara, Shoko Kure, Andrew T. Chan, Jeffrey A. Engelman, Peter Kraft, Lewis C. Cantley, Edward L. Giovannucci, Charles S. Fuchs, PIK3CA Mutation Is Associated With Poor Prognosis Among Patients With Curatively Resected Colon Cancer Journal of Clinical Oncology. ,vol. 27, pp. 1477- 1484 ,(2009) , 10.1200/JCO.2008.18.6544

Jeffrey A. Meyerhardt, Charles S. Fuchs, Shuji Ogino, Xiaoyun Liao, Teppei Morikawa, Paul Lochhead, Yu Imamura, Aya Kuchiba, Mai Yamauchi, Katsuhiko Nosho, Zhi Rong Qian, Reiko Nishihara, Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review Clinical Cancer Research. ,vol. 18, pp. 2257- 2268 ,(2012) , 10.1158/1078-0432.CCR-11-2410

Wendy De Roock, Bart Claes, David Bernasconi, Jef De Schutter, Bart Biesmans, George Fountzilas, Konstantine T Kalogeras, Vassiliki Kotoula, Demetris Papamichael, Pierre Laurent-Puig, Frédérique Penault-Llorca, Philippe Rougier, Bruno Vincenzi, Daniele Santini, Giuseppe Tonini, Federico Cappuzzo, Milo Frattini, Francesca Molinari, Piercarlo Saletti, Sara De Dosso, Miriam Martini, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi, Josep Tabernero, Teresa Macarulla, Frédéric Di Fiore, Alice Oden Gangloff, Fortunato Ciardiello, Per Pfeiffer, Camilla Qvortrup, Tine Plato Hansen, Eric Van Cutsem, Hubert Piessevaux, Diether Lambrechts, Mauro Delorenzi, Sabine Tejpar, None, Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis Lancet Oncology. ,vol. 11, pp. 753- 762 ,(2010) , 10.1016/S1470-2045(10)70130-3

Xiaoyun Liao, Paul Lochhead, Reiko Nishihara, Teppei Morikawa, Aya Kuchiba, Mai Yamauchi, Yu Imamura, Zhi Rong Qian, Yoshifumi Baba, Kaori Shima, Ruifang Sun, Katsuhiko Nosho, Jeffrey A. Meyerhardt, Edward Giovannucci, Charles S. Fuchs, Andrew T. Chan, Shuji Ogino, Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. The New England Journal of Medicine. ,vol. 367, pp. 1596- 1606 ,(2012) , 10.1056/NEJMOA1207756

En-Chih Liao, Ke-Chang Chang, Mites in the External Auditory Canal New England Journal of Medicine. ,vol. 367, pp. e19- ,(2012) , 10.1056/NEJMICM1010983