Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera.

摘要: A family of cancer cell cytotoxic cyclodepsipeptides, veraguamides A−C (1−3) and H−L (4−8), were isolated from a collection cf. Oscillatoria margaritifera obtained the Coiba National Park, Panama, as part Panama International Cooperative Biodiversity Group program. The planar structure veraguamide (1) was deduced by 2D NMR spectroscopy mass spectrometry, whereas structures 2−8 mainly determined combination 1H MS2/MS3 techniques. These new compounds are analogous to mollusk-derived kulomo’opunalide natural products, with two (C H) containing same terminal alkyne moiety. However, four veraguamides, A, B, K, L, also feature an alkynyl bromide, functionality that has been previously observed in only one other marine product, jamaicamide A. Veraguamide showed potent cytotoxicity H-460 human lung line (LD50 = 141 nM).