Georgamide, a new cyclic depsipeptide with an alkynoic acid residue from an Australian cyanobacterium.

摘要: A cyclic depsipeptide, georgamide (1), was isolated from an Australian cyanobacterium and characterized by spectroscopic means. The constituent units were five amino acid residues, one each of L-Thr, L-Pro, L-Val, N-Me-L-Val, N-Me-L-Phe, two hydroxy carboxylic acids, 2(S)-hydroxy-3(R)-methylpentanoic the unusual 2,2-dimethyl-3-hydroxy-7-octynoic acid. stereochemistry determined hydrolysis peptide followed derivatization HPLC comparison with standard samples.