Plasma Cytokine Parameters and Mortality in Patients With Chronic Heart Failure
作者： Mathias Rauchhaus , Wolfram Doehner , Darrel P. Francis , Constantinos Davos , Michael Kemp
DOI: 10.1161/01.CIR.102.25.3060
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摘要: BACKGROUND: Inflammatory immune activation is an important feature in chronic heart failure (CHF). Little known about the prognostic importance of tumor necrosis factor-alpha (TNF-alpha), soluble TNF-receptor 1 and 2 (sTNF-R1/sTNF-R2), interleukin-6 (IL-6), CD14 receptors (sCD14) CHF patients. METHODS AND RESULTS: In 152 patients (age 61+/-1 years, New York Heart Association [NYHA] class 2.6+/-0.1, peak VO(2) 17.3+/-0.6 mL. kg(-1). min(-1), mean+/-SEM) plasma concentrations variables were prospectively assessed. During a mean follow-up 34 months (>12 all patients), 62 (41%) died. Cumulative mortality was 28% at 24 months. univariate analyses, increased total trimeric TNF-alpha, sTNF-R1, sTNF-R2 (all P
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Dinarello Ca, Shames Bd, Meldrum Dr, Cleveland Jc, Cain Bs, Meng X, Banerjee A, Harken Ah, Ischemic preconditioning decreases postischemic myocardial tumor necrosis factor-alpha production. Potential ultimate effector mechanism of preconditioning. Circulation. ,vol. 98, ,(1998)
Shui-Ping Zhao, Ling-Hui Zeng, Elevated plasma levels of tumor necrosis factor in chronic heart failure with cachexia. International Journal of Cardiology. ,vol. 58, pp. 257- 261 ,(1997) , 10.1016/S0167-5273(96)02873-2
Eulàlia Roig, Josefina Orús, Carles Paré, Manel Azqueta, Xavier Filella, Felix Perez-Villa, Magda Heras, Ginés Sanz, Serum interleukin-6 in congestive heart failure secondary to idiopathic dilated cardiomyopathy. American Journal of Cardiology. ,vol. 82, pp. 688- 690 ,(1998) , 10.1016/S0002-9149(98)00388-9
Takayoshi Tsutamoto, Tomoko Hisanaga, Atsuyuki Wada, Keiko Maeda, Masato Ohnishi, Daisuke Fukai, Naoko Mabuchi, Masahide Sawaki, Masahiko Kinoshita, Interleukin-6 Spillover in the Peripheral Circulation Increases With the Severity of Heart Failure, and the High Plasma Level of Interleukin-6 Is an Important Prognostic Predictor in Patients With Congestive Heart Failure Journal of the American College of Cardiology. ,vol. 31, pp. 391- 398 ,(1998) , 10.1016/S0735-1097(97)00494-4
Ziad Dibbs, John Thornby, B.G White, Douglas L Mann, Natural variability of circulating levels of cytokines and cytokine receptors in patients with heart failure: implications for clinical trials Journal of the American College of Cardiology. ,vol. 33, pp. 1935- 1942 ,(1999) , 10.1016/S0735-1097(99)00130-8
Guillermo Torre-Amione, Samir Kapadia, Claude Benedict, Hakan Oral, James B. Young, Douglas L. Mann, Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD) Journal of the American College of Cardiology. ,vol. 27, pp. 1201- 1206 ,(1996) , 10.1016/0735-1097(95)00589-7
Torbjørn Omland, Asbjørn Aakvaag, Vernon V. S. Bonarjee, Kenneth Caidahl, Rolv Terje Lie, Dennis W. T. Nilsen, Johan A. Sundsfjord, Kenneth Dickstein, Plasma Brain Natriuretic Peptide as an Indicator of Left Ventricular Systolic Function and Long-term Survival After Acute Myocardial Infarction Comparison With Plasma Atrial Natriuretic Peptide and N-Terminal Proatrial Natriuretic Peptide Circulation. ,vol. 93, pp. 1963- 1969 ,(1996) , 10.1161/01.CIR.93.11.1963
K Swedberg, P Eneroth, J Kjekshus, L Wilhelmsen, Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. Circulation. ,vol. 82, pp. 1730- 1736 ,(1990) , 10.1161/01.CIR.82.5.1730
Pål Aukrust, Thor Ueland, Egil Lien, Klaus Bendtzen, Fredrik Müller, Arne K Andreassen, Ingvild Nordøy, Halfdan Aass, Terje Espevik, Svein Simonsen, Stig S Frøland, Lars Gullestad, Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. American Journal of Cardiology. ,vol. 83, pp. 376- 382 ,(1999) , 10.1016/S0002-9149(98)00872-8
Anita Deswal, Biykem Bozkurt, Yukihiro Seta, Semahat Parilti-Eiswirth, F. Ann Hayes, Consuelo Blosch, Douglas L. Mann, Safety and Efficacy of a Soluble P75 Tumor Necrosis Factor Receptor (Enbrel, Etanercept) in Patients With Advanced Heart Failure Circulation. ,vol. 99, pp. 3224- 3226 ,(1999) , 10.1161/01.CIR.99.25.3224