Is Alzheimer's disease a disorder of mitochondria-associated membranes?
作者： Eric A. Schon , Estela Area-Gomez
关键词:
摘要: The subcellular localization of presenilin-1 (PS1) and presenilin-2 (PS2), two proteins that, when mutated, cause familial Alzheimer's disease (AD), is controversial. We have discovered that mitochondria-associated membranes (MAM) - a specialized subcompartment the endoplasmic reticulum (ER) involved in lipid metabolism calcium homeostasis physically connects ER to mitochondria predominant location for PS1 PS2, gamma-secretase activity. hypothesize presenilins play role maintaining MAM function, not only altered amyloid-beta levels hyperphosphorylated tau, but also many other features AD (e.g., phospholipid cholesterol metabolism, aberrant homeostasis, abnormal mitochondrial dynamics) result from compromised function. may help reconcile disparate ideas regarding pathogenesis AD, under unifying hypothesis could explain both sporadic thereby taking research new fruitful direction.
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