Chemical small molecular drug for targeted therapy of cancers and preparation method of chemical small molecular drug

作者: Quan Xinxin , Butron Jane Claude , Dong Lizhi , Qiu Qiyu

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摘要: The invention relates to a chemical small molecular drug for targeted therapy of cancers and preparation method the drug; discloses structure cancers, as well purification drug. disclosed by has following beneficial effects that curative effect is better than conventional chemotherapeutic (BCNU or Temozolomide); virtue compound molecule, novel anti-cancer substitute also provided replace medication combining plurality drugs; cancer cells are found in mode like 'a biological cluster bomb', so damage normal reduced. Meanwhile, can be hydrolyzed vivo specifically block growth factor receptor signal transduction system (EGFR) cut off DNA replication.

参考文章(2)
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Qiyu Qiu, Anne-Laure Larroque, Bernard Gibbs, Youqiang Fang, Younes Lakhrissi, Jean-Paul Soucy, Shadreck Mzengeza, Zakaria Rachid, Bertrand Jean-Claude, Molecular analysis of the in vivo metabolism and biodistribution of metabolically and non-metabolically activated combi-molecules of the triazene class. Drug Metabolism Letters. ,vol. 3, pp. 1- 9 ,(2009) , 10.2174/187231209787176344